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KMID : 0380620130450050661
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Korean Journal of Food Science and Technology
2013 Volume.45 No. 5 p.661 ~ p.665
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Effect of Daebo (Castanea crenata) Inner Skin Extract on TMT-induced Learning and Memory Injury
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Kim Hyeon-Ju
Jeong Ji-Hee
Jo Yu-Na
Jin Dong-Eun
Jin Su-Il
Kim Man-Jo
Heo Ho-Jin
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Abstract
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The aim of this study was to investigate the anti-amnesic effect of daebo (Castanea crenata) extract on trimethyltin chloride (TMT)-induced learning and memory impairment, in vivo. The inner skin of daebo was extracted using distilled water under reflux conditions. At the end of the adaptation period, ICR mice were divided into a control group, a TMT injection group (negative control), and a sample group (C5: 5 mg/kg body weight; C10: 10 mg/kg body weight; and C20: 20 mg/kg body weight), and were tested with learning and memory tests. The ethylacetate fraction of the daebo inner skin extract was found to increase TMT-induced memory deficit in the Y-maze and passive avoidance test. Brain tissue analysis showed that the ethylacetate fraction of daebo extract lowered the acetylcholine esterase (AChE) activity and malondialdehyde (MDA) content of neuronal cells, both of which are indicative of lipid peroxidation.
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KEYWORD
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acetylcholinesterase, cognitive effect, daebo, trimethyltin
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